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The weight-loss industry tends to find medicine before the medicine finds its safeguards
no clear plateau) Zepbound: ~20% to 22.5% (long-term studies) Glycemic Control (T2D): Retatrutide: HbA1c reduction up to ~2.0% (Phase III) Zepbound: Strong, well-established HbA1c reductions (~2.0% to 2.4%) across Phase III trials Durability of Effect: Retatrutide: Sustained weight loss with continued decline over time Zepbound: Durable, but tends to plateau earlier Safety & Tolerability: Retatrutide: Higher rates of GI side effects
ClinicalTrials.gov is the starting point for finding active studies
Diabetes, Obesity & Metabolism, 26 Suppl 4, 1627
Follow-on versions of liraglutide and semaglutide, and possibly other polypeptides, should be clinically evaluated for efficacy and safety
Some people, like Erica, find their food noise silenced so entirely that they must make a concerted effort to remember to eat more
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